It is located in the middlewest part of Slovakia and forms a territorial band between the Bratislava Region and the rest of Slovakia. The region is smallest of all Slovak regions. Largest towns are Trnava, Piešťany, Hlohovec, Dunajská Streda and Sereď. Its major part is formed by the Danubian Lowland and Záhorie lowlands, which separates the crest of the Little Carpathians. Cultural, economic and administrative center of Trnava region is an ancient city of Trnava. It is the first free royal town in Slovakia. With a rich source of thermal and medicinal waters and developed spas, Trnava Region is an attractive region . Interesting spa towns are Smrdáky and world-famous Piestany. Piestany is the most important and biggest Slovak spa, designed for the treatment of rheumatic diseases and musculoskeletal system. Thanks to the quality of services it ranks among the top resorts of Europe and has large international clientele. There are ten springs with unique sulfuric thermal water and also healing sulphurous mud, which is among the finest in the world. The miraculous effects of local sources were reportedly known already in the 12th century. Small, quiet Spa Smrdáky lying in Zahorska basin has been named after the odor of springs, it has the highest content of hydrogen sulphide within the European medicinal waters. The skin diseases are being treated here with a high percentage of success.
Trnavsko region is among the earliest settled territories of Slovakia. Continuous historic settlement of the territory is testified to by numerous archaeological finds. In the past, an important trade route referred to as the Czech Road, which connected Czechia, Moravia with the Kingdom of Hungary led through this territory. Many castles were built along it in the 13th century (Ostrý Kameň Castle, Korlátka Castle, Dobrá Voda Castle). Now they are destinations of trippers.
City to know about: Trnava
City of Trnava originated from the village lying at an important crossroads of trade routes. The first written reference to Trnava dates from 1211. Trnava shortly after its establishment has gained a prominent position and in 1238, was the first town in (present-day) Slovakia to be granted a town charter (civic privileges) by the Hungarian king Bela IV.The name of the city is derived from the Slovak word tŕnie ("thornbush") which characterized the river banks in the region. It is the seat of a Roman Catholic archbishopric. Because of the many churches within its city walls, Trnava has often been called "parva Roma", i.e. "Little Rome", or more recently, the "Slovak Rome". Trnava – city walls belong to the oldest in Slovakia and meanwhile it belongs to the most important sites of its kind in Europe.
Region owes its reputation mainly unique natural springs of thermal mineral water , which springs from a depth of 2,000 meters. Mineral water in Piestany enact some specific compounds and the energy of the earth's magma, which are used to treat diseases for many years already. An interesting site is the protected area of Trnava ponds . Represents an important form of aquatic and wetland habitat at Trnava Hills, which greatly influenced the composition of biota, particularly birds of the region.